Description
E-7386 is an orally active CBP/beta-catenin modulator.In VivoE-7386 is an orally active CBP/beta-catenin modulator which can induce T cells infiltration into tumor and enhance antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. E-7386 shows significant antitumor activity in Wnt1 model. Infiltration of T cells is limited in vehicle control group, but T cell infiltration into tumors is clearly observed in E-7386 treatment group. MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:CBP/beta-catenin