Description
Alirinetide (GM604) is an oligopeptide containing 6 amino acids. Alirinetide can cross the blood-brain barrier and can be used for the research of multiple neurodegenerative diseases.In VitroAlirinetide (GM604) (0.1-10 mg/mL; 24 h) prevents SH-SY5Y cell death. Alirinetide (48 h) predominantly represses Parkinson’s disease-associated genes in SH-SY5Y cells, these genes were largely associated with the mitochondrial protein complex and respiratory chain. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: SH-SY5Y cells Concentration: 0.1, 1 or 10 mg/mL Incubation Time: 24 h Result: Led to dose-dependent rescue of cell survival, with complete recovery of cell viability at the highest dose (10 mg/mL).In VivoAlirinetide (GM604) (0-20 mg/kg; i.v.; twice daily for 5 days) improves behavioral, biochemical, and histological features in the 6-OHDA mouse model. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 mice, 6-hydroxydopamine (6-OHDA) mouse model Dosage: 0, 1, 5, 10 or 20 mg/kg Administration: Intravenous injection, twice daily for 5 days Result: Almost completely abrogated 6-OHDA effects at the highest dose, leading to improved motor performance, increased numbers of TH-positive neurons in the substantia nigra, and increased brain levels of dopamine, 3,4-Dihydroxyphenylacetic acid (DOPAC) and\nhomovanillic acid (HVA).Form:Solid