FIPI from MedChemExpress

Description

FIPI is a phospholipase D (PLD) inhibitor with an IC₅₀ for PLD1 and PLD2 of about 25 nM. FIPI regulates cytoskeletal recombination, cell diffusion and chemotaxis. FIPI can be used in cancer research. In addition, FIPI can enhance the secretion and aggregation of platelet dense particles, inhibit thrombosis, reduce ischemic stroke infarct volume and improve nerve function

Product Specs
ItemFIPI
CompanyMedChemExpress
Price $85.00Supplier Page View Company Product Page
Catalog NumberHY-12807
Quantity5 mg
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity98.00%
TypeChemical
Research AreaNeurological Disease; Inflammation/Immunology; Cardiovascular Disease; Cancer

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(1) Nicotinamide mononucleotide promotes female germline stem cell proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodelingCell BiosciApril 17, 2025Hong Zhou, Yujie Liu, Geng G. Tian, Ji Wu(HY-149302, MCE) was prepared in dimethyl sulfoxide (DMSO) at 50 mM and diluted with medium as needed. FIPI (HY-12807, MCE) was dissolved in DMSO at 10 mM and similarly diluted before use. Animals Female C57BL/6 mice

(2) Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cellsInternational journal of toxicologyDecember 1, 2011Secor JD, Kotha SR, Gurney TO, Patel RB, Kefauver NR, Gupta N, Morris AJ, Haley BE, Parinandi NL.

(3) 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxisMolecular pharmacologyMarch 1, 2009Su W, Yeku O, Olepu S, Genna A, Park JS, Ren H, Du G, Gelb MH, Morris AJ, Frohman MA.

(4) Optimization of halopemide for phospholipase D2 inhibitionBioorganic & medicinal chemistry lettersApril 15, 2007Monovich L, Mugrage B, Quadros E, Toscano K, Tommasi R, LaVoie S, Liu E, Du Z, LaSala D, Boyar W, et al.

(5) [New strategies for preventing allergies (interview by Waldtraud Paukstadt)]MMW Fortschritte der MedizinMay 4, 2006von Mutius E.

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FIPI from MedChemExpress

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