Merbarone from MedChemExpress | Biocompare.com

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Merbarone

Description

Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent

Product Specs
ItemMerbarone
CompanyMedChemExpress
Price $88.00Supplier Page View Company Product Page
Catalog NumberHY-19024
Quantity10 mM * 1 mL
TypeChemical
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.49%
Research AreaCancer

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(1) Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavageThe Journal of biological chemistryJuly 10, 1998Fortune JM, Osheroff N.

(2) Differences in inhibition of chromosome separation and G2 arrest by DNA topoisomerase II inhibitors merbarone and VM-26Cancer researchApril 1, 1995Chen M, Beck WT.

(3) Initial mechanistic studies with merbarone (NSC 336628)Biochemical pharmacologySeptember 15, 1985Cooney DA, Covey JM, Kang GJ, Dalal M, McMahon JB, Johns DG.

(4) 5-(N-phenylcarboxamido)-2-thiobarbituric acid (NSC 336628), a novel potential antitumor agentBiochemical pharmacologyJune 1, 1985Brewer AD, Minatelli JA, Plowman J, Paull KD, Narayanan VL.

(5) Studies on Yersinia (Pasteurella) pseudotuberculosis. I. Sources and serological classification of the organism isolated in JapanNihon juigaku zasshi. The Japanese journal of veterinary scienceOctober 1, 1970Tsubokura M, Itagaki K, Kawamura K.

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