Filipin complex from MedChemExpress

Product Specs
ItemFilipin complex
CompanyMedChemExpress
Price $66.00Supplier Page View Company Product Page
Catalog NumberHY-N6716
Research AreaInfection
Quantity5 mg
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
TypeChemical

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(1) Therapy-induced cholesterol biosynthesis drives lung cancer dormancy and drug resistanceJ Clin InvestApril 15, 2026Yikai Zhao, Yijia Zhou, Linnuo Pan, Geng G. Tian, Hsin-Yi Huang, Shijie Tang, Ming Lu, Zhangsen Zhou, Peng Zhang, Luonan Chen, et al.(PFA) for 10 minutes at room temperature. Then cells were stained for 2 hours with 0.05 mg/mL filipin (HY-N6716, MCE) in PBS containing 10% FBS, and rinsed 3 times with PBS. The images were acquired using a Leica TCS SP8

(2) Obinutuzumab induces lysosomal destabilization via sphingomyelin-dependent inhibition of TRPML2Scientific ReportsFebruary 3, 2026Jinkyung Oh, Narae Jin, Sunhyung Kwon, Changsin Lee, Hyungjun Baek, Donghyuk Lee, Joo Young KimOBI (0.3 µg/ml) treatment for an additional 2 h. Endocytosis inhibition was performed using filipin (HY-N6716, MCE), dynasore (S8047, Sellekchem), pitstop2 (HY-115605, MCE), Sphingomyelinase (S7651-10UN, Sigma),

(3) Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer ProgressionAdvanced ScienceJanuary 28, 2026Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, et al.per milligram or the number of cells. In addition, cholesterol was labeled with a filipin complex (HY‐N6716, MCE, Shanghai, China) and then detected by flow cytometry [49]. 4.5 Immunohistochemical Staining Analysis The

(4) Carbon-based quantum dots enhance platelets aggregation through migrasomes biogenesisJournal of NanobiotechnologyJanuary 17, 2026Ang Li, Leiliang ZhangNSC23766 (HY-15723), carbonyl cyanide 3-chlorophenylhydrazone (CCCP) (HY-100941), and filipin complex (HY-N6716) were acquired from MedChemExpress (Princeton, NJ, USA). FITC-labeled WGA (GTX01502) was obtained from

(5) Fenofibrate suppresses Mycoplasma bovis infection via autophagy-mediated cholesterol regulation in bovine mammary epithelial cells and murine mammary tissueFrontiers in Cellular and Infection MicrobiologyJanuary 12, 2026Maolin Xu, Tian Wang, Xian Deng, Yuxin Liu, Zimeng Zhu, Herman W. Barkema, Eduardo R. Cobo, John P. Kastelic, Xueying Zhou, Bo Han(Sulfobutylether-β-Cyclodextrin, HY-17031), DMSO (Dimethyl sulfoxide, HY-Y0320C), and Filipin complex (HY-N6716) were purchased from MedChemExpress (Monmouth Junction, NJ, USA). Anti-LAMP1 antibody (67300-1-Ig),

(6) Hepatocyte SAMHD1 Deficiency Attenuates Hepatic Steatosis via Suppression of SREBP Activation in a Mouse Model of Metabolic-Associated Steatotic Liver DiseaseInternational Journal of Biological SciencesJanuary 1, 2026Guangfa Yin, Yongqing Liu, Xianhe Teng, Shuqi Sun, Beibei Chen, Xinyu Wang, Tao Yang, Ying Wang, Hanyang Xu, Yu-sheng Chen, et al.using confocal microscopy. For Filipin staining, cryosections were incubated with 0.25 mg/mL Filipin (HY-N6716, MCE) in PBS for 1 hour at room temperature in the dark, followed by mounting and confocal imaging. TUNEL

(7) Mitochondria relay cholesterol signal exacerbates osteoarthritis in miceNature CommunicationsNovember 19, 2025Yiyang Ma, Yidan Pang, Chenglong Liu, Yuchen Tian, Kaiwen Zheng, Meng Yao, Xiaofeng Liu, Ruomu Cao, Yiwei Zhao, Zhikai Zheng, et al.sectioned in 10-µm slices. Sections were incubated with filipin complex (50 μg/mL, MedChemExpress, HY-N6716) 30 min in room temperature, mounted with ProLong Diamond antifade medium (ThermoFisher, P36961). Seahorse

(8) Diabetes exacerbates myasthenia gravis by enhancing pathological thymic output via the GPR183-7α,25-OHC axisJ NeuroinflammationOctober 29, 2025Jing Dong, Xin Shi, Xu-Dong Gu, Ying Yang, Yi-Lin He, Yang Zhou, Heng Li, Tong Du, Wei-Yue Si, Shu-Li Wei, et al.(PFA) for 30 min at room temperature, and incubated with filipin solution (100 µg ml⁻¹, MedChemExpress, HY-N6716) overnight at 4 °C; images were acquired using a confocal laser scanning microscope (Nikon A1R). Hematoxylin

(9) Cholesterol-rich lipid rafts mediate endocytosis as a common pathway for respiratory syncytial virus entry into different host cellsMicrobiology SpectrumSeptember 2, 2025Anqi Zhou, Bao Xue, Jiayi Zhong, Junjun Liu, Ran Peng, Fan Wang, Yuan Zhou, Jielin Tang, Qi Yang, Xinwen Chen(AK0529, HY-109142, MCE), presatovir (GS-5806, HY-16727, MCE), NH4Cl (A9434, Sigma), filipin complex (HY-N6716, MCE), CPZ (S5749, Selleck), EIPA (HY-101840, MCE), MβCD (HY-101461, MCE), cytochalasin D (CytoD, HY-N6682,

(10) Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung CancerAdvanced ScienceSeptember 1, 2025Yueren Yan, Ning Wang, Bowen Xing, Min Yang, Jun Shang, Yufang Bao, Lixing Xiao, Ningxia Zhang, Yunpeng Ren, Chunnan Liu, et al.HY‐13259, CAS No.133407‐82‐6), EHT1864 (Cat. No. HY‐16659, CAS No.754240‐09‐0), and Filipin (Cat. No. HY‐N6716, CAS No.11078‐21‐0) were purchased from MCE Chemicals. Methyl‐β‐cyclodextrin (MβCD, Cat. No. 332615,

(11) Cholesterol confers resistance to Apatinib-mediated ferroptosis in gastric cancerCell BiosciJuly 4, 2025Zhiwei Li, Chenxin Liu, Minghao Wang, Riqing Wei, Ru Li, Kaihua Huang, Huayuan Liang, Guoxin Li, Liying ZhaoBeyotime) for 10 min at room temperature. Next, the sections were stained with 0.05 mg/mL Filipin complex (HY-N6716, MedChemExpress) in PBS containing 10% fetal bovine serum (FBS) for 2 h and then rinsed three times

(12) GP73-dependent regulation of exosome biogenesis promotes colorectal cancer liver metastasisMolecular cancerMay 26, 2025Huang L, Wei M, Li H, Yu M, Wan L, Zhao R, Gao Q, Sun L, Hou X, Mo Y, et al.25-hydroxycholesterol (HY-113134), 27-hydroxycholesterol (HY-N2371), campesterol (HT-N1459), filipin complex dye (HY-N6716), GW4869 (HY-19363), 4’,6-diamidino-2-phenylindole (DAPI, HY-D1738) and PKH26 (HY-D1451) were purchased

(13) Porphyromonas gingivalis aggravates atherosclerotic plaque instability by promoting lipid-laden macrophage necroptosisSignal Transduct Target TherMay 23, 2025Xiaofei Huang, Mengru Xie, Yixuan Wang, Xiaofeng Lu, Feng Mei, Kaiwen Zhang, Xinlong Yang, Guangjin Chen, Ying Yin, Guangxia Feng, et al.(10 μM, No. 25892, Cayman) for 30 min to detect ox-LDL uptake, or stained with Filipin (0.1 mg/mL, HY-N6716, MedChemExpress) for 30 min to detect free cholesterol content. After extensive PBS washing, cells were

(14) APOL4-mediated intracellular cholesterol trafficking is essential for glioblastoma cell growthBMC CancerMay 21, 2025Mingxiang Zhang, Tao Yang, Youcun Qian(DYKDDDDK) antibody (#F1804) were purchased from Sigma-Aldrich. Stearic acid (#HY-B2219), Filipin complex (#HY-N6716), U18666A (#HY-107433) were purchased from MCE. Fatty acid free BSA (#A602448) were purchased from Sangon

(15) Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeuticsNat CommunMarch 10, 2025Xufei Bian, Qian Guo, Lee-Fong Yau, Ling Yang, Xiaoyou Wang, Shikang Zhao, Shiqiong Wu, Xurong Qin, Zhi-Hong Jiang, Chong LiPharmaceutical Tech Co., Ltd. (Shanghai, China). Chlorpromazine hydrochloride (HY-B0407A), filipin complex (HY-N6716), monensin sodium (HY-N0150), brefeldin A (HY-16592), colchicine (HY-16569), and GR 103691 (HY-101382)

(16) PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of MicrogliaAdvanced ScienceJuly 1, 2023Tao Wang, Yunxia Zhou, Yunping Fan, Hao Duan, Xiaoyu Guo, Jinlong Chang, Youheng Jiang, Changxue Li, Zhang Fu, Yunfei Gao, et al.4% PFA, followed by overnight incubation with a combination of 20 µg mL−1 of Filipin complex (MCE, #HY‐N6716) and primary antibodies in 10% bovine serum albumin in PBS, and then incubated with secondary antibodies.

(17) Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundleseLifeNovember 1, 2022Ge Gao, Shuyu Guo, Quan Zhang, Hefei Zhang, Cuizhen Zhang, Gang Pengdrug",AM1-43,Biotium,70024, "Chemical compound, drug",Efavirenz,MCE,HY-10572, "Chemical compound, drug",Filipin,MCE,HY-N6716, "Chemical compound, drug",Lyso-Tracker Red,Beyotime,C1046, "Chemical compound, drug",Phalloidin,Beyotime,C1033/C2203S, "Chemical

(18) Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer's tau pathologySignal transduction and targeted therapyJune 13, 2022Huang S, Zhang Z, Cao J, Yu Y, Pei G.incubated with 1.5 mg/ml glycine for 10 min at RT. Then sections were stained with 0.05 mg/ml filipin (MCE, HY-N6716) in PBS containing 10% FBS for 2 h and rinsed three times with PBS. For lipid droplet staining, sections

(19) Skimmed Bovine Milk-Derived Extracellular Vesicles Isolated via “Salting-Out”: Characterizations and Potential Functions as NanocarriersFrontiers in NutritionOctober 28, 2021Xiao-Hui Tan et al.Shanghai, China) such as chlorpromazine hydrochloride (Cat. No. HY-B0407A, MCE), filipin complex (Cat. No. HY-N6716, MCE), LY294002 (Cat. No. HY-10108, MCE), dynasore (Cat. No. HY-15304, MCE). All inhibitors were dissolved

(20) Role of lipid rafts in porcine reproductive and respiratory syndrome virus infection in MARC-145 cellsBiochemical and biophysical research communicationsOctober 28, 2011Huang L, Zhang YP, Yu YL, Sun MX, Li C, Chen PY, Mao X.

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Filipin complex from MedChemExpress

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Filipin complex from MedChemExpress

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