Cyclopamine from MedChemExpress

Product Specs
ItemCyclopamine
CompanyMedChemExpress
Price $66.00Supplier Page View Company Product Page
Catalog NumberHY-17024
Quantity10 mM * 1 mL
TypeChemical
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.95%
Research AreaCancer

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(1) Pre-assembly of biomolecular condensate seeds drives RSV replicationNatureApril 2, 2026Dhanushika Ratnayake, Marie Galloux, Sanne Boersma, Marko Noerenberg, Christina Sizun, Carlos Sacristan, Julien Sourimant, Anke J. Lakerveld, Anne T. Gelderloos, Leonie Apperloo, et al.324693, Merck), cyclopamine (CPM; 4 µM; inhibits RSV infection by disorganizing and hardening VFs; HY-17024, MedChemExpress)37,38 and puromycin dihydrochloride (puromycin; 0.1 mg ml−1; a tyrosyl-tRNA mimic that

(2) Liquid-liquid phase separation mediated immune evasion of respiratory syncytial virus against oligoadenylate synthetase-RNase L pathwayPLOS PathogensMarch 27, 2026Woo Yeon Hwang, Michael G. Rosenfeld, Soohwan Oh, Young-Chan Kwonfixed. Immunofluorescence staining was performed as previously described. For LLPS hardening, 5 μM CPM (HY-17024–1mg, MCE) was treated for 1 h before LLPS disruption. Naked dsRNA purification from RSV-infected cells

(3) HHIPL2 positively governs Hedgehog signaling to accelerate non-small cell lung cancer progression via enhancing HNRNPC-mediated HNF1A mRNA stabilizationCell Death & DiseaseDecember 18, 2025Ning Mu, Fanrong Liu, Xiangqing Song, Biao Wang, Yilin Zhu, Lingbing Li, Lingxiao Yang, Huacong Sui, Jinfu Wang, Fengyuan Gao, et al.mycoplasma. Reagents and antibodies The chemicals used in our experiments were Triptolide (HY-32735), Cyclopamine (HY-17024), and Actinomycin D (HY-17559), which were purchased from MedChemExpress. Puromycin Dihydrochloride

(4) SLC25A39 regulates Hedgehog signaling to promote tumor progression and sorafenib resistance in hepatocellular carcinomaSci RepOctober 15, 2025Qian Qiu, Hehe Yin, Lulu Zhang, Wen Xu, Shiwei Zhu, Qianqian Zhang, Mengqi Zhao, Yuting Qian, Yatong Ruan, Hui Zhang, et al.potential of combining SLC25A39 knockdown with sorafenib, we first determined the IC50 of cyclopamine (MCE, HY-17024), a specific HH pathway inhibitor, to identify an appropriate drug concentration (Fig. 6J). Subsequently,

(5) Loss of UBE3A impacts both neuronal and non-neuronal cells in human cerebral organoidsCommun BiolMay 30, 2025R. Chris Estridge, Z. Begum Yagci, Dilara Sen, Tyler J. Johnson, Gautami R. Kelkar, Travis S. Ptacek, Jeremy M. Simon, Albert J. Keunghydrochloride (MedChemExpress, HY-10256A), baricitinib (MedChemExpress, HY-15315), cyclopamine (MedChemExpress, HY-17024), gallein (MedChemExpress, HY-D0254), glycyrrhizic acid (MedChemExpress, HY-N0184), H-89 dihydrochloride

(6) Type 3 deiodinase activation mediated by the Shh/Gli1 axis promotes sepsis-induced metabolic dysregulation in skeletal musclesBurns TraumaJanuary 28, 2025Gang Wang, Tao Gao, Yijiang Liu, Jianfeng Duan, Huimin Lu, Anqi Jiang, Yun Xu, Xiaolan Lu, Xiaoyao Li, Yong Wang, et al.part, rats were randomly divided into a sham group (n = 6), CLP group (n = 10), and CLP + Cyclopamine (HY- 17024, MCE, 40 mg/kg, intraperitoneal injection 2 h before CLP modeling) group (n = 10). 24 h after CLP modeling

(7) Tai/NCOA2 suppresses the Hedgehog pathway by directly targeting the transcription factor Ci/GLIProceedings of the National Academy of SciencesNovember 19, 2024Xuan Yu, Xinyu Wang, Kaize Ma, Dongqing Gao, Yanran Deng, Dafa Zhou, Wenhao Ding, Yunhe Zhao, Qingxin Liu, Zizhang Zhoutreated with 100 ng/mL C24II (MedChemExpress, HY-P7407) (70) or 20 µM cyclopamine (MedChemExpress, HY-17024) (71) for 24 h before cell harvesting. 48 h after transfection, cells were collected for immunoprecipitation (IP

(8) M2 macrophages mediate fibrotic scar formation in the early stages after cerebral ischemia in ratsNeural regeneration researchOctober 1, 2023Huang JG, Ren JX, Chen Y, Tian MF, Zhou L, Wen J, Song XS, Wu YL, Yang QH, Jiang PR, et al.sulfoxide, recombinant rat IL4 (800 ng/d in 10 µL PBS), or 20 µM cyclopamine (Cyc, Medchemexpress, Cat# HY-17024) by intracerebroventricular injection. A constant infusion rate of 0.5 µL/h for 7 or 14 days was controlled

(9) Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagyJournal of cellular and molecular medicineAugust 1, 2021Ma L, Li C, Lian S, Xu B, Lv H, Liu Y, Lu J, Ji H, Li S, Guo J, et al.67‐68‐5) and d‐Galactosamine (CAS NO: 1772‐03‐8) were obtained from Sigma Chem. Co. Cyclopamine (CAS NO: HY‐17024) was obtained from MCE. Co. Antibodies against NFE2L2 (1:1000; cat. no. Ab89443), Keap1 (1:1000; cat.

(10) Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascadeCell death and differentiationJuly 1, 2021Wang W, Yan T, Guo W, Niu J, Zhao Z, Sun K, Zhang H, Yu Y, Ren T.(ACS-4500). Following reagents were purchased from MedChemExpress (Monmouth, NJ, USA): cyclopamine (HY-17024), cycloheximide (CHX) (HY-12320), MG-132 (HY-13259), PF-04691502 (HY-15177), GANT61 (HY-13901); human recombinant IHH

(11) Overexpression of laminin α4 facilitates proliferation and migration of fibroblasts in knee arthrofibrosis by targeting canonical Shh/Gli1 signalingConnective tissue researchJuly 1, 2021Wan Q, Liu F, Zhang J, Chen H, Yan L, Li X, Sun Y, Wang J.

(12) Mitochondrial Protection and Against Glutamate Neurotoxicity via Shh/Ptch1 Signaling Pathway to Ameliorate Cognitive Dysfunction by Kaixin San in Multi-Infarct Dementia RatsOxidative medicine and cellular longevityJanuary 1, 2021Li X, Wen W, Li P, Fu Y, Chen H, Wang F, Dai Y, Xu S.1001726877), and glutamate (Lot # SLCD3953) were obtained from Sigma-Aldrich (USA). Cyclopamine (Cyc, Cat.# HY-17024/CS-0633) was provided by Med Chem Express (MCE). The glutamic acid measurement kit (Cat.NoA07411) was

(13) Vascular endothelial growth factor 165 inhibits pro-fibrotic differentiation of stromal cells via the DLL4/Notch4/smad7 pathwayCell death & diseaseSeptember 12, 2019Lv H, Nan Z, Jiang P, Wang Z, Song M, Ding H, Liu D, Zhao G, Zheng Y, Hu Y.inhibited in cells using KYA1797K (Catalog #HY-101090; MedChemExpress, USA), cyclopamine (Catalog #HY-17024; MedChemExpress, USA), and DAPT (Catalog #HY-13027; MedChemExpress, USA), respectively. RNA isolation

(14) Reduced Smoothened level rescues Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's diseaseJournal of genetics and genomics = Yi chuan xue baoMay 20, 2018Ma W, Wu M, Zhou S, Tao Y, Xie Z, Zhong Y.

(15) Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathwayBioorganic & medicinal chemistry lettersJanuary 15, 2009Peukert S, Jain RK, Geisser A, Sun Y, Zhang R, Bourret A, Carlson A, Dasilva J, Ramamurthy A, Kelleher JF.

(16) Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumoursNatureOctober 23, 2003Berman DM, Karhadkar SS, Maitra A, Montes De Oca R, Gerstenblith MR, Briggs K, Parker AR, Shimada Y, Eshleman JR, Watkins DN, et al.

(17) Hedgehog is an early and late mediator of pancreatic cancer tumorigenesisNatureOctober 23, 2003Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernández-del Castillo C, Yajnik V, et al.

(18) [Ethmoidal arteries: origin, course, regions supplied and anastomoses]Acta anatomicaJanuary 1, 1979Lang J, Schäfer K.

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Cyclopamine from MedChemExpress

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Cyclopamine from MedChemExpress

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