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Protein Biochemistry
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FIDAS-5
FIDAS-5 from MedChemExpress
Be the first to write a review!
Citations:
(7)
Supplier Page
Supplier Page from
MedChemExpress for
FIDAS-5
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Description
FIDAS-5 is a potent and orally active
methionine S-adenosyltransferase 2A (MAT2A)
inhibitor with an
IC
50
of 2.1 µM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for
MAT2A
binding. FIDAS-5 has anticancer activities
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
FIDAS-5
Company
MedChemExpress
Price
$90.00
Supplier Page
View Company Product Page
Catalog Number
HY-136144
Type
Chemical
Applications
Bioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Quantity
1 mg
Purity
98.46%
Research Area
Cancer
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MedChemExpress
1 Deer Park Drive, Suite F
MONMOUTH JUNCTION
,
NJ
08852
United States
Phone
: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910
Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com
Company Profile
Website:
medchemexpress.com
Citations (7)
(1)
Targeting the Mapk13‐Tcf1‐Slc7a5 Axis via One‐Carbon Metabolic Regulation to Prevent Chronic Allograft Vasculopathy
Advanced Science
March 1, 2026
Wang Yi, Di Wu, Jing Liu, Shi Chen, Liu Song, Bin Xie, Aini Xie, Peixiang Lan, Zhishui Chen
HY‐18850
,
MCE
) were used in ex vivo experiments and the construction of the CAV model.
FIDAS‐5
(cat#
HY‐136144
,
MCE
) and
DZ2002
(cat#
HY‐18620
,
MCE
) were used in ex vivo experiments. 4.12 Statistics Analysis Data
(2)
Dietary methionine mitigates immune-mediated damage by enhancing renal clearance of cytokines
Cell Metabolism
February 3, 2026
Katia Troha, Shrikaar Kambhampati, Arianna Insenga, Christian M. Metallo, Janelle S. Ayres
reviews and drug titration pilot experiments93–94.
FIDAS-5
injections
FIDAS-5
(
MedChemExpress
, catalog #
HY-136144
) was prepared according to the manufacturer’s instructions. The drug was administered via oral gavage
(3)
Regulation of INSM1 Gene Expression and Neuroendocrine Differentiation in High-Risk Neuroblastoma
Biology (Basel)
December 22, 2025
Chiachen Chen, Siyuan Cheng, Xiuping Yu, Yisheng Lee, Michael S. Lan
5′-iodotubercidin
(5′-IT,
HY15424
), 3-Deazaneplanocin (D9, an analog of DZNep-HCl,
HY10442
), and
FIDAS-5
(
HY-136144
) were obtained from
MedChemExpress
(Monmouth Junction, NJ, USA). Antibodies,
INSM1
(A8,
sc-271408
),
(4)
MAT2A promotes atherosclerotic plaque vulnerability by mediating epigenetic reprogramming of macrophages
Nature communications
December 16, 2025
Du Z, Wan P, Du M, Li S, Yan Q, Sun S, Tang C, Jiang Z, Li S, Shi G,
et al
.
MAT2A
inhibition model63,64, ApoE-/-
mice
were administered the MAT2A inhibitor
FIDAS-5
(10 mg/kg,
HY-136144
,
MedChemExpress
, New Jersey, USA) by intragastric gavage. Treatment was initiated after 10 weeks of
(5)
S-adenosylmethionine addiction confers sensitivity to methionine restriction in
KMT2A
-rearranged acute lymphoblastic leukemia
Haematologica
November 1, 2025
Trisha Tee, Titine J.J. Ruiter, Shuiyan Wu, Weiya Zhang, Dorette van Ingen van Ingen Schenau, Maria Rodionova, Danique Wajon, Britt M.T. Vervoort, Kari J.T. Grunewald, Marjolein Bosma,
et al.
with a 10-fold dilution series of each drug in the presence or absence of
FIDAS-5
(
MedChemExpress
, #
HY-136144
) for 72 h. Cell viability was measured using an
MTT assay
. Details can be found in the Online Supplementary
(6)
Methionine-SAM metabolism-dependent ubiquinone synthesis is crucial for ROS accumulation in ferroptosis induction
Nature Communications
October 17, 2024
Chaoyi Xia, Pinghui Peng, Wenxia Zhang, Xiyue Xing, Xin Jin, Jianlan Du, Wanting Peng, Fengqi Hao, Zhexuan Zhao, Kejian Dong,
et al.
(
A7007
,
Sigma
), S-adenosylhomocysteine (SAH) (A9384, Sigma), Methionine (Met) (M9625, Sigma),
FIDAS-5
(
HY-136144
,
MCE
),
PF-9366
(S0435, Selleck), Adenosine Dialdehyde (ADOX) (S8608, Selleck),
Mitoguazone
(MGBG) (
HY-15763
,
(7)
Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A
ACS chemical biology
April 19, 2013
Zhang W, Sviripa V, Chen X, Shi J, Yu T, Hamza A, Ward ND, Kril LM, Vander Kooi CW, Zhan CG,
et al
.
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FIDAS-5 from MedChemExpress
Supplier Page
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$90.00
Product Specs
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