Rotenone from MedChemExpress

Product Specs
ItemRotenone
CompanyMedChemExpress
Price $50.00Supplier Page View Company Product Page
Catalog NumberHY-B1756
Quantity500 mg
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.74%
TypeChemical
Research AreaNeurological Disease; Cancer

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(1) Hematopoietic cell‑specific knockout Hspa9 impairs natural killer cell function and alters the Akt/mTOR axis in miceExperimental and Therapeutic MedicineJuly 24, 2026Xiaokang Zeng, Jieyu Zhang, Caiying Liang, Jie Yao, Zuqiang Wumedium containing recombinant human IL-2 (1,000 IU/ml) for 4 h. Rotenone (MedChemExpress; cat. no. HY-B1756) was used to induce ROS at a concentration of 1 µM for 1 h. For the detection of ROS generation, NK cells

(2) Integrative Multi-Omics Analysis Reveals a Mitochondrial-Immune Axis Associated With Neoadjuvant Chemotherapy Response in High-Grade Serous Ovarian CancerAdv Sci (Weinh)July 20, 2026Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, et al.inhibitors including IACS‐010759 (MCE, HY‐112037) with the beginning concentration of 2.5 uM, Rotenone (MCE, HY‐B1756) with the beginning concentration of 0.123 uM, VLX600 (MCE, HY‐12406) with the beginning concentration

(3) Genetic ablation of Sfxn5 induces mitochondrial dysfunction and precipitates lethal metabolic crisis in miceiScienceJuly 17, 2026Huan Zhang, Cuihong Wang, Yumeng Zhang, Yiming Xiang, Sijia Fan, Ling Meng, Jingjing Qin, Jiashi Guo, Zhenting He, Ziling Deng, et al.250-05 Enrofloxacin,"ZHONGLONG SHENLI Pharmaceutical Co., Ltd",Cat# zsy016 Rotenone,MedChemExpress,Cat# HY-B1756 Oligomycin,MedChemExpress,Cat# HY-N6782 FCCP,MedChemExpress,Cat# HY-100410 Antimycin A,MaoKangBio,Cat#

(4) Semaglutide targets muscle mitochondria to regulate glutamine metabolism and treat osteoarthritisiScienceJune 19, 2026Yuchen Tian, Zhikai Zheng, Yiyang Ma, Fang Ye, Yidan Pang, Zhicheng Zhang, Zhiwei Li, Changqing Zhang, Junjie GaoIL-1β,Novoprotein,Cat# C042 Palmitic acid,MCE,Cat# HY-N0830 Semaglutide,TargetMol,Cat# T19850 Rotenone,MCE,Cat# HY-B1756 Antimycin A,Sigma,Cat# A8674 Telaglenastat,MCE,Cat# HY-12248 Glutamine,MCE,Cat# HY-N0390 ,, Critical

(5) Aging Impairs Macrophage Phagocytosis Through Mitochondrial ROS-Induced Collagen ProductionAging CellJune 15, 2026Yuming Wang, Xin Xu, Nuanqin Shen, Ping Han, Liuyi Wu, Yi Jin, Yiming Sun, Lanlan Xiao, Jinyou Li, Lan Wang, et al.(Catalog no. K2721, for macrophage depletion) were purchased from APExBIO, USA. Rotenone (Catalog no. HY‐B1756, a mitochondrial complex I inhibitor) and Diethyl succinate (Catalog no. HY‐Y0836) were purchased from

(6) Chemical modulation of Miro1 alleviates cell-type-specific vulnerabilities in Friedreich’s ataxiaCell Chemical BiologyJune 8, 2026Sujyoti Chandra, Chulhwan S. Kwak, Zehui Du, Giuseppe Barisano, Kong T. Nguyen, Vlad Vinogradov, Xinnan Wang18k / well. A drug at 10 μM was applied for 24 h and then Antimycin A (40 μM) or Rotenone (0.5 μM; HY-B1756, MedChemExpress) was applied for 6 h. Next, MTT assay was performed following manufacturer’s instruction

(7) Extracellular biogenic nanoscale mitochondria reprogram the wound microenvironment via ROS scavenging independent of cellular uptakeMaterials Today BioJune 1, 2026Fang Lin, Jing Liu, Yue Ding, Kexin Ma, Qingshu Meng, Xiaohui Zhou, Qingliu Zhang, Hao Hu, Zhongmin Liu, Xiaoting Liangoxidative stress. Additional chemical treatments included the following: rotenone (500 nM; MCE, Cat# HY-B1756), PX-12 (10 μM; MCE, Cat# HY-13734), Dynasore (5 μM; MCE, Cat# HY-15304), MNS (1 μM; MCE, Cat# HY-78263),

(8) A prototype-augmented graph representation learning framework for identifying brain disorder-associated genes and facilitating drug repurposingPLoS Comput BiolMay 29, 2026Jiafang Li, Yifei Li, Siying Lin, Jiahua Rao, Huiying Zhaoplates (5,000 cells/well) overnight and treated with a gradient of rotenone concentrations (0.25–16 μM; HY-B1756, MedChemExpress) or vehicle (0.1% DMSO) for 8 h. Cell viability was assessed by CCK-8 assay, and the

(9) Uridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in miceNature CommunicationsApril 29, 2026Jingyue Chen, Jianing Shen, Dongxu Li, Guangjun Huang, Rui Wang, Xiaofan Sun, Meijie Chen, Tianyi Liao, Liying Yan, Peng Yuan, et al.GSSG, and the GSH/GSSG ratio was used to assess redox balance. Rotenone and RSL3 treatment Rotenone (HY-B1756, MedChemExpress) was dissolved in DMSO and then diluted in M2 medium to final concentrations of 1, 2,

(10) Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell ProfilingCell ProliferationApril 27, 2026Hao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Hongbo Zhangpopulation was treated with a different inhibitor, with a total of 14 inhibitors tested, including rotenone (HY‐B1756, MedChemExpress), Mdivi‐1 (HY‐15886, MedChemExpress), UK‐5099 (HY‐15475, MedChemExpress), devimistat

(11) Parkin regulates NLRP3 degradation through chaperone-mediated autophagy to suppress PANoptosis and protect dopaminergic neurons in Parkinson’s diseaseJournal of NeuroinflammationApril 22, 2026Dongyan Zheng, He Zhang, Ailun Xie, Huilin Xiao, Duanqin Guan, Zhefan Xie, Jiankun Luo, Jianwei Cao, Tianji Lin, Lifei Xing, et al.experimental group, with no more than 5 mice housed per cage to ensure optimal housing conditions. Rotenone (HY-B1756), MCC950 (HY-12815), and CA77.1 (HY-134923) were purchased from MedChemExpress (Shanghai, China), and

(12) Mitochondrial translocation of MDM2 and TFAM reprograms metabolism in treatment-refractory cancersnpj Precision OncologyApril 16, 2026Jie Qing Eu, Nur Afiqah Binte Mohamed Salleh, Jayshree Hirpara, Naoto Ohi, Emiri Omori Takaki, Tuan Zea Tan, Ju Ee Seet, Susan Swee-Shan Hue, Shu Jun Chan, Dorothy Xi Yue Lim, et al.Biosciences,FP1495001KT Penicillin-Streptomycin,Gibco,15140-122 Proteinase K,Invitrogen,25530-049 RNase A,Thermo Scientific,EN0531 Rotenone,MedChemExpress,HY-B1756 RPMI-1640,Gibco,11875-093 "Seahorse XF RPMI Medium, pH 7.4, 500 mL",Agilent,103576-100 Standard Human

(13) POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 LactylationAdvanced ScienceMarch 7, 2026Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou(L7022, Merck), Glucose (D9434, Merck) RS6212 (HY‐150753, MCE), Syrosingopine (S9907, Selleck), Rotenone (HY‐B1756, MCE), MSC‐4381 (HY‐132301, MCE), and DAPI (0100‐20, Southern Biotech) were also purchased from the

(14) Amino acid restriction sensitizes lung cancer cells to ferroptosis via GCN2-dependent activation of the integrated stress responseRedox BiologyMarch 1, 2026Viktor Antonsson Garellick, Nadia Gul, Parvin Horrieh, Dyar Mustafa, Angana A.H. Patel, Martin Dankis, Samantha W. Alvarez, Johanna Berndtson, Saeed Mahdavi, Maria Schwarz, et al.Sigma-Aldrich), oligomycin (HY–N6782; MedChemExpress), puromycin dihydrochloride (A1113803; Gibco), rotenone (HY–B1756; MedChemExpress), RSL3 (SML2234; Sigma-Aldrich), resatorvid (HY-11109; MedChemExpress), and Z-VAD-FMK

(15) Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in CancersAdvanced ScienceFebruary 13, 2026Xu Xiao, Cheng Lu, Hao Chen, Jing Zhou, Yunyun Hu, Haonan Di, Guoqiang Su, Xiaomei Yanhydrazone (CCCP, HY‐100941), oligomycin A (OligA, HY‐16589), bedaquiline (BDQ, HY‐14881), rotenone (HY‐B1756), metformin (HY‐17471), VLX600 (HY‐12406), BPTES (HY‐12683), C‐968 (HY‐12682), CB‐839 (HY‐11248), and

(16) Comprehensive analysis of mitochondrial unfolded protein response related genes for prognosis and therapeutic response in pancreatic cancerFrontiers in ImmunologyFebruary 5, 2026Chengqing Li, Cuiling Lu, Zheng Ma, Ting Zhao, Mingming Xiao, Zhonglei Xu, Zhenxing Sun, Qihao Wu, Lei Wang, Liang Zhaoproduction. To induce UPRmt, cells at approximately 80% confluency were treated with 1 µM rotenone (MCE, HY-B1756) for 24 hours. Quantitative real-time polymerase chain reaction We extracted total RNA from cells

(17) Porcine epidemic diarrhea virus promotes viral replication via ROS/HIF-1α-mediated glycolysisRedox biologyFebruary 1, 2026Xu Y, Zhang J, Yin C, Liu L, Wang Z, Fu S, Fan R, Zhao Y, Miao J.dimethyloxalylglycine (DMOG, HIF-1α activator, HY-15893), N-Acetyl-l-cysteine (NAC; HY-B0215), Rotenone (ROT; HY-B1756), and Carbonyl cyanide 3-chlorophenylhydrazone (CCCP; HY-100941) were purchased from MedChemExpress

(18) HVEM costimulatory domain boosts CAR T cell efficacy against solid tumors via enhanced TRAF-mediated TNF signalingCell Communication and SignalingJanuary 8, 2026Shishuo Sun, Wanxin Zhao, Yibing Liang, Ying Xue, Qihong Li, Yifan Yuan, Zhenyu Wang, Xiaoge Gao, Yizhou Yao, Haiheng Xu, et al.1.0 µM carbonyl cyanide p-trifluoromethoxy phenylhydrazone (FCCP; HY-100410, MCE), 40 nM rotenone (HY-B1756, MCE), and 1 mM antimycin A (A8674, Sigma) every 20 min to detect the dynamic OCR. Meanwhile, cells

(19) Lactate bridges mesangial cells to the differentiation of follicular helper T cells in lupus nephritisNature CommunicationsDecember 11, 2025Mengdi Liu, Huiyan Ji, Jiaxin Lei, Ming Zheng, Lingyi Li, Xingyu Zhai, Hongmin Wang, Ting Liu, Qinghua Cao, Lin Xu, et al.of self-DNA Self-DNA was extracted after inducing apoptosis in PBMCs with rotenone (MedChemExpress, HY-B1756, 30 μM) for 6 days63. Apoptotic DNA was extracted using the phenol-isoamyl alcohol method, involving

(20) Thapsigargin suppresses porcine hemagglutinating encephalomyelitis virus replication by disrupting host energy metabolismVirologica SinicaDecember 1, 2025Qianhan Jia, Zi Li, Yanfang Yu, Zezhao Cao, Ruizhao Qiu, Jing Zhang, Wenqi He, Junchao Shi2-deoxy-d-glucose (2-DG, HY-13966), 3-PO (HY-19824), oxamate (HY–W013032A), UK-5099 (HY-15475), rotenone (ROT, HY-B1756), 2-thenoyltrifluoroacetone (TTFA, HY-D0190), oligomycin (OLM, HY-N6782), and 2-NBDG (HY-116215) were

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Rotenone from MedChemExpress

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Rotenone from MedChemExpress

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