Description
Gnetol is a phenolic compound isolated from the root of Gnetum montanum. Gnetol potently inhibits COX-1 (IC50 of 0.78 µM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC50 of 4.5 µM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities