Description
A microbial metabolite and an ACE inhibitor (IC50 = 7 µg/ml for the bovine lung enzyme); selective for ACE over nine peptidases (IC50s = >100 µg/ml for all); reduces systolic blood pressure in SHRs at 25 and 50 mg/kg; an iron chelator that inhibits the degradation of erbstatin and enhances erbstatin-induced reduction of tumor growth in an MCF-7 mouse xenograft model