Description
A positive allosteric modulator of α7 nAChRs; enhances ACh-, nicotine-, or choline-induced currents in Xenopus oocytes expressing recombinant human α7 nAChRs (EC50s = 0.7, 0.6, and 0.5 µM, respectively); improves sensory gating deficits in a paired auditory stimulus paradigm in mice at 0.3 and 1 mg/kg; decreases the latency to find the platform in the Morris water maze test in a rat model of parasagittal fluid-percussion-induced TBI