Description
A ROCK1 inhibitor (IC50 = 7 nM for the human kinase); selective over RSK1 and p70S6K (IC50s = 398 and 1,000 nM, respectively) and is greater than 100-fold selective over a panel of 31 additional kinases; induces relaxation in precontracted isolated rat aortic rings (EC50 = 256 nM); decreases mean arterial blood pressure in spontaneously hypertensive rats at 30 mg/kg