Description
An adenosine A1 receptor positive allosteric modulator; binds to adenosine A1 receptors (Kb = 11 µM); enhances adenosine-induced inhibition of forskolin-induced cAMP production in CHO cells expressing recombinant human adenosine A1 receptors from 0.3-30 µM; increases the mechanical paw withdrawal threshold in a rat model of neuropathic pain induced by partial sciatic nerve ligation at 10 and 30 µg/animal