Description
An inhibitor of ALK5 (IC50 = 2.5 nM); selective for ALK5 over p38 MAPK (IC50 = 12 µM); reduces renal fibrosis in a model of unilateral ureteral obstruction using transgenic Col1a1-Luc Tg rats at 1, 3, and 10 mg/kg; reduces proteinuria and glomerulosclerosis and improves renal function in heminephrectomized rats in a model of anti-Thy-1 glomerulonephritis at 0.3 and 1 mg/kg