Description
An mPGES-1 inhibitor; inhibits PGE2 production in both SK-N-AS human and BV-2 mouse cells (IC50s = 0.1 and 2 µM, respectively); reduces LPS-induced increases in a variety of cytokines, including CCL2, IL-6, and TNF-α, in the mouse hippocampus, but not kidney, without affecting the mRNA expression of Cox2 at 10 mg/kg, i.p