Description
An ionizable cationic lipid that has been used in combination with other lipids in the formation of LNPs; LNPs containing CL4F8-6 and encapsulating an mRNA reporter accumulate specifically in the mouse liver after intravenous administration; LNPs containing CL4F8-6 and encapsulating mCas9 and sgTtr have been used to induce CRISPR-mediated gene knockdown in mice resulting in a reduction of serum levels of TTR