Description
A ROCK1 and ROCK2 inhibitor (IC50s = 51 and 19 nM, respectively); selective for ROCK1 and ROCK2 over PKACα and PKC (IC50s = 2,100 and >10,000 nM, respectively); reduces intraocular pressure in cynomolgus monkey at 0.4%; increases the outflow facility of the aqueous humor in rabbit eyes at 0.4%; decreases intraocular pressure, retinal ganglion cell death, and thinning of inner retinal layers, as well as improves retinal function, in an EAAT1 knockout mouse model of normal tension glaucoma