Description
Novel, cell-permeable inhibitor of protein kinase Mzeta (PKMzeta), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMzeta-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5uM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo