Description
17(R)-Protectin D1 is an aspirin-triggered epimer of the specialized pro-resolving mediator protectin D1.1It decreases leukotriene B4-induced transendothelial migration of Human polymorphonuclear (PMN) neutrophils when used at concentrations ranging from 0.1 to 10nM. 17(R)-Protectin D1 (0.01-10 ng) reduces the recruitment of neutrophils in a mouse model of TNF-alpha-induced peritonitis