Description
Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1, which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase then to MCTR2 by gamma-glutamyl transferase. MCTR2 accelerates tissue regeneration in planaria (1 and 100nM). Pretreatment with MCTR2 prior to E Coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E Coli by macrophages. When administered at a dose of 100 ng 12h post E Coli infection in a mouse model of peritonitis, MCTR2 selectively reduced the amount of the eicosanoids PGD2 and PGF2alpha in the exudate