Description
AMG-548 is an orally active and selective p38alpha inhibitor (Ki=0.5nM), shows slightly selective over p38beta (Ki=36nM) and >1000 fold selective against p38gamma and p38delta and is also extremely potent in the inhibition of whole blood LPS stimulated TNFalpha (IC50=3nM)[1]. AMG-548 inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms delta and epsilon[2]