Description
Linearmycin A is a polyene antibiotic that has been found inStreptomyces.1It is active against the bacteriaS. aureusandE. coli(MICs = 3.1 and 1.6 ug/disc, respectively), the fungiS. cerevisiaeandC. albicans(MICs = 0.1 and 1.6 ug/disc, respectively), and the plant pathogenic fungusA. nigerin disc assays (MIC = 0.2 ug/disc). Linearmycin A induces lysis and degradation ofB. subtilisas a component ofStreptomycesMg1 extract.2