Description
High affinity and subtype selective alpha6beta2 and alpha4beta2 partial agonist (Ki values are 12 and 2nM for rat alpha6beta2 and alpha4beta2 receptors respectively). Has low affinity for alpha3beta4 and alpha7 receptors (Ki values are 4.8 and 13uM for Human alpha3beta4 and rat alpha7 receptors respectively). Stimulates dopamine release from striatal slices in vitro. Attenuates nicotine-induced self-administration and conditional place preference in rats