Description
AS604872 is a selective antagonist of the FP receptor. AS604872 significantly accelerated degeneration of the media in both cerebral artery and aorta as evidenced by thinning of the media and disruption of the elastic lamina and promoted IA and aortic dissection. AS604872 can be used to make models of these vascular diseases with extensive degeneration. AS604872 also inhibits spontaneous uterine contraction