Description
DBPR-110 is a nonstructural protein 5A (NS5A) inhibitor. DBPR-110 reduced the reporter expression of the HCV1b replicon with a EC(50) and a selective index value of 3.9+/-0.9 pM and >12, 800, 000, respectively. DBPR-110 reduced HCV2a replicon activity with an EC(50) and a selective index value of 228.8+/-98.4 pM and >173, 130, respectively