Description
Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor II is a reversible, cell-permeable inhibitor of VEGFR2's kinase activity (IC50 = 70nM). It less potently inhibits the platelet-derived growth factor receptor beta (PDGFRbeta; IC50 = 920nM) and related receptor and non-receptor tyrosine kinases. VEGFR2 kinase inhibitor II blocks the growth of HumanuMbilical vein endothelial cells stimulated with either VEGF or PDGF (IC50s = 110nM and 2uM, respectively)