Description
Inhibitor of NF-kappaB kinase 2 (IKK2, also known as IKKbeta) acts as part of an IKK complex in the canonical NF-kappaB pathway, phosphorylating inhibitors of NF-kappaB (IkappaBs) to initiate signaling. NF-kappaB signaling can also occur through a non-canonical, IKK/IkappaB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM). [1] It is used to evaluate the role of the canonical, IkappaB-dependent NF-kappaB signaling pathway in cellular responses.[2][3]