Description
5alpha,6alpha-epoxy Cholestanol is an oxysterol and a metabolite of cholesterol produced by oxidation.[1] 5alpha,6alpha-epoxy Cholestanol accumulates in MCF-7 breast cancer cells in a reactive oxygen species-dependent manner following tamoxifen and PBPE application and induces triacylglycerol biosynthesis by binding to liver x receptor beta (LXRbeta). [2] 5alpha,6alpha-epoxy Cholestanol levels are increased in rat aorta and mesenteric artery following orchidectomy, an effect that can be prevented by a DHA-supplemented diet.[1] Levels are also increased in post-mortem frontal and occipital cortex of patients with Alzheimer's disease. [3]