Description
Citropin-1.1 is isolated from Litoria citropa. It has bacteriostatic action for Gram-positive bacteria. Citropin-1.1 strongly inhibits the formation of NO by neuronal nitric oxide synthase (nNOS) at micromolar concentrations. It acts by a non-competitive mechanism, probably by binding to calcium/calmodulin and as a consequence blocking calmodulin attachment to nNOS