Description
An inhibitor of NEDD8-activating enzyme; inhibits NEDDylation of UBC12 in a cell-free assay using recombinant human NAE; selectively inhibits NEDDylation over SUMOylation and ubiquitination in A549 cells; inhibits the growth of A549 cells (GI50 = 5.5 µM); inhibits tumor growth in an AGS gastric adenocarcinoma mouse xenograft model at 60 mg/kg