Description
A CCK1 receptor antagonist (Ki = 0.3 nM); selective for CCK1 over CCK2 (Ki = 342 nM); inhibits CCK-8-induced amylase release in isolated dispersed rat pancreatic acini (IC50 = 25.4 nM); reduces CCK-8-induced decreases in gastric emptying and food intake in rats and inhibits CCK-8-induced contractions of colon and gall bladder in rabbits and cats, respectively (ED50s = 140, 321, 34, and 210 µg/kg, respectively); enhances morphine-induced increases in tail-flick latency and prevents the development of morphine tolerance in rats at 1 mg/kg; induces apoptosis and cell cycle arrest at the G1/G0 phase in, and inhibits the migration of, 5637 cells at 25 µM