CFM 4 from Cayman Chemical

An inhibitor of the APC2-CARP-1 protein-protein interaction; inhibits the binding of APC2 to CARP-1 (IC50 = 0.75 µM); reduces the proliferation of a variety of breast, prostate, and colon cancer cells in a concentration-dependent manner; induces cell cycle arrest at the G0 phase in MDA-MB-468 breast cancer cells and apoptosis in T47D breast cancer cells at 20 µM; nanostructure lipid carrier-encapsulated CFM 4 reduces tumor growth in an A549 NSCLC mouse xenograft model at 40 mg/kg every other day