Description
An allosteric antagonist of CXCR1 and CXCR2 (IC50s = 1 and 100 nM, respectively); reduces ischemia and reperfusion-induced hepatic PMN recruitment, hepatic MPO levels, and serum ALT levels in a rat model of hepatic ischemia at 3, 15, and 30 mg/kg; decreases systolic blood pressure in spontaneously hypertensive rats at 5 mg/kg; reduces tumor volume and the number of intratumor cancer stem cells in a SUM159 mouse xenograft model when administered in combination with docetaxel