Description
A resuscitative agent; binds to 5-HT receptors in isolated rat cerebral cortex and brainstem membranes (Kis = 178.9 and 103.7 nM, respectively); increases the latency to tail-flick in mice from 0.05-0.45 mg/kg, an effect that can be reversed by BRL 44408 and imiloxan but JP-1302; increases MAP, cardiac output, and survival following bleeding-induced hypotension in a rat model of hemorrhagic shock from 0.006-0.05 mg/kg in combination with hypertonic saline