Description
A PROTAC that drives ALK degradation; degrades NPM-ALK in Karpas-299 cells at 10-300 nM, an effect that can be blocked by MG-132; cytotoxic to ALK-dependent Karpas-299 cells (IC50 = 0.1265 nM) but not non-ALK-dependent THP-1 cells (IC50 = 2,704 nM); reduces tumor volume in an NCI H3122 mouse xenograft model at 25, 50, and 100 mg/kg