Description
A multivalent ionizable cationic lipid; has been used in the generation of liposomes complexed with plasmid DNA for use in vitro and in vivo; has been used in combination with DC-Chol and 1,2-DOPE in the generation of lipid nanocarriers for siRNA delivery to A549 cells; GL67-containing liposomes, in complex with plasmid DNA for the gene encoding CFTR, leads to the expression of functional wild-type CFTR in HEK293 cells; aerosol administration of GL67-containing liposomes, in complex with plasmid DNA for the gene encoding CFTR, increases trachea and whole lung mRNA levels of CFTR