Description
An ionizable cationic lipid and a dendrimer; has been used in the generation of LNPs for the delivery of siRNA, mRNA, sgRNA, ssDNA, and PEGylated BODIPY dyes; LNPs containing 4A3-SC8 and encapsulating siRNA targeting Factor VII selectively accumulate in the liver and decrease hepatic Factor VII activity in mice; intratumoral administration of LNPs containing 4A3-SC8 and encapsulating HDR elements correct the DNA encoding GFPY66H in a HEK293 mouse xenograft model; intravenous administration of LNPs containing 4A3-SC8 and encapsulating an mRNA reporter and a PEGylated BODIPY dye have been used for tumor imaging in mice