Description
A mGluR1 allosteric antagonist (IC50 = 2.6 nM in CHO cells expressing the human receptor); is selective for mGluR1 over mGluR5 by >2,000-fold, as well as mGluR2, -4, -6, -7, or -8 at 10 µM in CHO cells expressing the human receptors; reduces methamphetamine-induced hyperlocomotion in mice at 1-10 mg/kg, p.o