Description
A TRPA1 antagonist (IC50 = 0.131 µM in a calcium mobilization assay); selective for human TRPA1 over human TRPV1 and TRPV4, rat TRPV1, TRPV3, and TRPM8, and a panel of 40 additional targets at 10 µM; reduces the number of AITC-induced tail flinches in rats at 10 and 30 mg/kg