Description
An inhibitor of HDAC6 (IC50 = 17 nM); selective for HDAC6 over HDAC1-5 and HDAC7-11 (IC50s = 386->10,000 nM), inhibits tubulin acetylation in HeLa cervical cancer cells (EC50 = 58.9 nM) and the proliferation of A375 melanoma and HeLa cells (IC50s = 45 and 49 nM, respectively); inhibits microtubule formation in MDA-MB-231 cells; reduces tumor growth in HCT116, A2780, and MCF-7 mouse xenograft models from 12.5-50 mg/kg