Description
A Syk inhibitor (IC50 = 5.6 nM); selective for Syk over a panel of 392 other kinases at 1 µM; inhibits M. tuberculosis PknG (IC50 = 4.4 µM); inhibits the proliferation of, and induces apoptosis in, primary AML cells at 5 µM; prevents RANKL- and M-CSF-induced osteoclastogenesis in isolated mouse BMDMs (IC50 = 145 nM); reduces disease severity in a mouse model of collagen-induced arthritis at 5 or 45 mg/kg