Description
An ionizable cationic lipid; has been used in combination with other lipids for the formation of LNPs; immunization with SARS-CoV-2 spike glycoprotein mRNA in IC8- and manganese-containing LNPs induces IgG responses to SARS-CoV-2 Delta and Omicron variants in mice; administration of mRNA encoding B7-H3 X CD3 BiTE antibodies in IC8-containing LNPs reduces tumor growth in MV4-11 and A375 mouse xenograft models