Description
A DHODH inhibitor; inhibits DHODH by 89% in HeLa cells at 100 nM; inhibits hypoxia-induced VEGF-A synthesis in HeLa cells (EC50 = 1.64 nM); inhibits viral replication of SARS-CoV-2, HCV replicon genotype 1b, poliomyelitis virus, RVF virus, and Ebola virus in Vero, Huh7, HeLa, HeLa, and Vero 76 cells, respectively (EC50s = 2.6, 36, 0.57, 13, and 9.1 nM, respectively); inhibits production of IL-17F and IL-17A induced by CD3 and CD28 in Th17 cells