Description
An active metabolite of caffeine and theophylline; scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 77% in isolated human erythrocyte membranes at 500 µM; induces contractions in isolated rabbit duodenal, jejunal, and ileal preparations; induces relaxation in isolated rabbit ascending colon preparations; intracerebral administration induces clonic convulsions in mice (ED50 = 360 nmol/animal); has been found in urinary caliculi