Description
A vitamin D receptor antagonist (IC50 = 2.9 µM in a fluorescence polarization assay); inhibits VDR transactivation in HEK293 cells (IC50 = 20.8 µM); decreases the viability of OVCAR-8, OV-2008, SKOV3, Caov-3, and IGROV-1 ovarian cancer cells in a concentration-dependent manner; reduces RXRα and importin-4 protein levels in OV-2008 cells at 250 nM; decreases PD-L1 levels in primary human AML cells at 500 nM; reduces tumor growth in an SH-SY5Y neuroblastoma mouse xenograft model at 10 mg/kg; LNPs containing MeTC7 selectively localize to the pancreas in mice