Description
A PKM2 inhibitor (IC50 = 2.95 µM); selective for PKM2 over PKM1 and PKLR (IC50s = 16.71 and 8.2 µM, respectively); cytotoxic to HCT116, HeLa, and H1299 cells (IC50s = 0.18, 0.29, and 1.56 µM, respectively); induces apoptosis and autophagy in SKOV3 cells at 1, 2.5, and 5 µM; reduces tumor volume and weight in an SKOV3 mouse xenograft model at 5 mg/kg