AS1517499 from MedChemExpress

Product Specs
ItemAS1517499
CompanyMedChemExpress
Price $110.00Supplier Page View Company Product Page
Catalog NumberHY-100614
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.17%
TypeChemical
Molecular Weight397.86
FormulaC₂₀H₂₀ClN₅O₂
Research AreaInflammation/Immunology; Cancer

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(1) Estrogen Promotes Melanogenesis Through Facilitating M2 Macrophage Skewing in MelasmaInt J Mol SciJuly 6, 2026Shen Lin, Linwang Su, Yifei Deng, Yingying Qu, Dongyan Shen, Kun Yao, Qi Wang, Mengting Ouyang, Qingfang Xusignal-regulated kinase 1/2 inhibitor U0126 (HY-12031A), and STAT6 phosphorylation inhibitor AS1517499 (HY-100614) were from MedChemExpress (Monmouth Junction, NJ, USA). VEGF165/121 monoclonal antibody (69025-1-IG)

(2) JMJD3 regulates the M2-like macrophage polarization and promotes the growth of breast cancer cells via STAT6/IRF4 axisPLoS OneApril 9, 2026Juan Lyu, Enqin Wang, Shanmei Lyu, Ying Qian, Fen Ye, Xiuping Xu, Qing Wang, Tao Lu, Liangfeng Hu, Hongkun Xu, et al.NJ, USA) and 20 ng/ml interleukin-13 (IL-13) (HY-P70568; MCE, Monmouth Junction, NJ, USA). AS1517499 (HY-100614, MCE) is a novel and potent STAT6 inhibitor. To investigate the role of STAT6 in M2-like macrophage

(3) Mechanism of IL-4 mediated RPL19 promoting malignant progression in HER2 positive breast cancerBreast Cancer ResearchFebruary 21, 2026Nana Zhang, Jian Zhang, Junchao Shao, Zhenfeng Huang, Jinxing Zhang, Hao Wang, Liangshuang Lv, Zibo Shen, Peng Zhang, Bing Liu, et al.(αIL4R,5ug/ml,R&D Systems, Cat# MAB230-100) or STAT6 pathway inhibitor [41] (AS1517499,5uM,Medchemexpress, HY-100614) in RPL19-overexpressing groups attenuated the RPL19-mediated promotion of breast cancer progression

(4) TGM2 Aggravates Acute Pancreatitis by Impairing Macrophage Efferocytosis Through Inhibition of the STAT6–GAS6 AxisAdvanced ScienceFebruary 17, 2026Xuxu Liu, Zhiwei Du, Liyi Wang, Zhihong Xie, Ziang Meng, Yi Zheng, Heming Wang, Yuanhang He, Dongbo Xue(000117), and ALC‐0159 (029104) were purchased from MeloPEG (China). Cystamine (HY‐124476), AS1517499 (HY‐100614), Batiraxcept (HY‐P99463), and caerulein (HY‐A0190) were obtained from Med Chem Express (MCE, USA).

(5) SOX4-STAT6-MTHFD2 axis drives hepatocellular carcinoma progression and treatment resistanceCell Death & DiseaseJanuary 3, 2026Chia-Lung Tsai, Ming-Chin Yu, Cheng-Lung Hsu, Hsiang-Yu Tang, Yun-Shien Lee, Lang-Ming Chi, Sey-En Lin, Mei-Ling Cheng, Heng-Yuan Hsu, Chi-Neu Tsai(NADPt-NADPH)/NADPH. Cell proliferation assay Hep3B cells (1 × 10⁴/per 96 well) were treated with AS1517499 (HY-100614, MedChemExpress, USA), DS18561882 (HY-130251, MedChemExpress, USA), sorafenib (HY-10201, MedChemExpress,

(6) SLC25A1-Mediated Cholesterol Accumulation Promotes Endometriosis Progression by Enhancing Endometrial Stromal Cell Proliferation, Invasion, and M2 Macrophage PolarizationInt J Biol SciJanuary 1, 2026Pusheng Yang, Tao Wang, Yaxin Miao, Wenwen Liu, Yiping Zhu, Jing SunTreatment Chemical reagents, including CHO (HY-N0322), Methyl-β-cyclodextrin (Mal-β-CD, MCE, HY-18593), AS1517499 (HY-100614), and CTPI-2 (HY-123986) were purchased from MedChemExpress (MCE, Shanghai, China) and were dissolved

(7) IL-4-JAK1-STAT6 Pathway Mediates Electroacupuncture's Effect on Microglial M2 Polarization to Treat Inflammatory Bowel Disease With Comorbid DepressionCNS Neurosci TherAugust 18, 2025Sihui Cao, Jingjing Yang, Lin Chen, Zuqiang Li, Lv Jia, Yuxiang Huang, Zhanwei Xu, Penghui Lu, Jin Liu, Qiong Liu, et al.p‐STAT6 inhibitor groups were intraperitoneally injected with a p‐STAT6 inhibitor (10 mg/kg; AS1517499; HY‐100614, MedChemExpress). The CON and MOD groups underwent the same handling procedure, isoflurane inhalation

(8) STAT1 and STAT6 orchestrate Cbs transcription and transsulfur metabolism in microglia and contribute to parkinson’s disease-related neuroinflammationCellular and Molecular Life SciencesJuly 30, 2025Yang Liu, Zhen Wang, Ya-Ting Ma, Yu-Xuan Chen, Xin-Yi Qian, Xiao-Ou Hou, Bo Wan, Hai-Gang Ren, Li-Fang HuUSA), TRITC-phalloidin (40734ES75, YEASEN, China), fludarabine (S1491, Selleck, China), AS1517499 (HY-100614, MCE, China) and [5-(4-hydroxyphenyl)−3 H-1,2-dithiole-3-thione] (ADT-OH) (HY-109582, MCE, China). The

(9) Sleep deprivation-induced sympathetic activation promotes pro-tumoral macrophage phenotype via the ADRB2/KLF4 pathway to facilitate NSCLC metastasisiScienceMay 16, 2025Shuxian Yin, Jiali Wang, Yunlong Jia, Xiaoyi Wang, Yan Zhao, Tianxu Liu, Wei Lv, Yuqing Duan, Song Zhao, Sheng Wang, et al.proteins" ,, IL-4,ABclonal,RP01161 isoprenaline,Cayman,Cat#15592 "ICI118,551",GLPBIO,Cat#72795-01-8 AS1517499,MCE,Cat#HY-100614 D-Luciferin (potassium salt),Cayman,Cat#14681 6-hydroxydopamine,Cayman,Cat#25330 PD-1 inhibitor,Bio X Cell

(10) STAT6 blockade ameliorates thyroid function in Graves’ disease via downregulation of the sodium/iodide symporterEndocrine ConnectionsDecember 1, 2024Qian Yang, Qinnan Zhang, Fanfan Pan, Bingbing ZhaIL-4 (Proteintech Group Inc., Wuhan, China), and AS1517499 (a potent STAT6 phosphorylation inhibitor, HY-100614, MCE, NJ, USA). Cells were harvested and lysed with radioimmunoprecipitation assay buffer (CoWin Biosciences,

(11) STAT6 blockade ameliorates thyroid function in Graves’ disease via downregulation of the sodium/iodide symporterEndocr ConnectOctober 1, 2024Qian Yang, Qinnan Zhang, Fanfan Pan, Bingbing ZhaIL-4 (Proteintech Group Inc., Wuhan, China), and AS1517499 (a potent STAT6 phosphorylation inhibitor, HY-100614, MCE, NJ, USA). Cells were harvested and lysed with radioimmunoprecipitation assay buffer (CoWin Biosciences,

(12) The iNKT cell ligand α-GalCer prevents murine septic shock by inducing IL10-producing iNKT and B cellsFrontiers in ImmunologySeptember 17, 2024Yun Hoo Park, Sung Won Lee, Tae-Cheol Kim, Hyun Jung Park, Luc Van Kaer, Seokmann Hong(serotype 0111:B4) was purchased from Sigma-Aldrich (St. Louis, MO, USA). STAT6 inhibitor (AS1517499, Cat. #HY-100614) and IL10 inhibitor (AS101, Cat. #2446/10) were purchased from MedChemExpress (Monmouth Junction, NJ,

(13) Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in Ewing sarcomaNature communicationsJune 21, 2024Yu L, Deng Y, Wang X, Santos C, Davis IJ, Earp HS, Liu P.from Polysciences, Inc. IL-4 was purchased from R&D Systems (204-IL-010). SN-38 (HY-13704), AS1517499 (HY-100614) and filgotinib (HY-18300) were purchased from MedChemExpress. UNC2025, UC5293, UNC5567, and MRX-2843

(14) Targeting STAT6 to mitigate sepsis-induced muscle atrophy and weakness: Modulation of mitochondrial dysfunction, ferroptosis, and CHI3L1-Mediated satellite cell lossBiochemistry and Biophysics ReportsMarch 1, 2024Zhiyong Sheng, Zhihong Yu, Meng Wang, Rui Zhou, Shenjian Chen, Xin Yu, Fuxing Liexperiment, mice were intraperitoneally injected with AS1517499 (STAT6 inhibitor, 10 mg/kg; MedChemExpress, HY-100614) 1 h prior to establishing the CLP model. The various biological tissues from each group were collected

(15) Cancer-associated fibroblast-derived periostin promotes papillary thyroid tumor growth through integrin-FAK-STAT3 signalingTheranosticsJanuary 1, 2024Jin X, Deng Q, Ye S, Liu S, Fu Y, Liu Y, Wu G, Ouyang G, Wu T.incubated with anti-IL-4R antibody (Abcam, ab271041, 5 μg/mL) or AS1517499 (500 nM) (MedChemExpress, HY-100614) for 30 minutes. After 24 hours or indicated time, cells were collected and detected by qRT-PCR or western blot

(16) The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophagesCell Host & MicrobeNovember 1, 2022Arne L. ten Hoeve, Laurence Braun, Matias E. Rodriguez, Gabriela C. Olivera, Alexandre Bougdour, Lucid Belmudes, Yohann Couté, Jeroen P. J. Saeij, Mohamed-Ali Hakimi, Antonio BarraganSTAT3 and IKK-2 inhibitor,MedChemExpress,Cat# HY-10074 AS1517499 STAT6 inhibitor,MedChemExpress,Cat# HY-100614 CellTracker Orange CMTMR Dye,Thermo Fisher,Cat# C2927 CellTracker Deep Red Dye,Thermo Fisher,Cat#

(17) STAT6 Upregulates NRP1 Expression in Endothelial Cells and Promotes AngiogenesisFrontiers in oncologyJanuary 1, 2022Gao P, Ren G, Liang J, Liu J.(50 ng/mL) (213-ILB, R&D systems, Minneapolis, MN, USA) and STAT6 inhibitor, AS1517499 (AS) (1 mM) (HY-100614, MCE, NJ, USA). Knockdown of STAT6 and NRP1 Small interference RNA of human STAT6 and human NRP1 were

(18) PP2Acα promotes macrophage accumulation and activation to exacerbate tubular cell death and kidney fibrosis through activating Rap1 and TNFα productionCell death and differentiationSeptember 1, 2021Liang Y, Sun X, Wang M, Lu Q, Gu M, Zhou L, Hou Q, Tan M, Wang S, Xue X, et al.0111: B4, Sigma-Aldrich). To inhibit Stat6 phosphorylation, BMDMs were treated with AS1517499 (cat: HY-100614, MCE, USA) for 30 min, then stimulated with LPS. To block TNFα signaling, primary tubular epithelial cells

(19) Autocrine Production of Interleukin-34 Promotes the Development of Endometriosis through CSF1R/JAK3/STAT6 signalingScientific reportsNovember 14, 2019Lin K, Ma J, Peng Y, Sun M, Xu K, Wu R, Lin J.(R&D Systems, 5265-IL; Minneapolis, MN, USA), 100 nM AS1517499 (a specific STAT6 inhibitor, Medchemexpress, HY-100614; Monmouth Junction, NJ, USA) or 50 ng/mL IL-34 antibody (Abcam, ab101443; Cambridge, MA, USA) for 48

(20) A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in miceAmerican journal of respiratory cell and molecular biologyNovember 1, 2009Chiba Y, Todoroki M, Nishida Y, Tanabe M, Misawa M.

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AS1517499 from MedChemExpress

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AS1517499 from MedChemExpress

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