VE-821 from MedChemExpress

Product Specs
ItemVE-821
CompanyMedChemExpress
Price $61.00Supplier Page View Company Product Page
Catalog NumberHY-14731
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.67%
TypeChemical
Molecular Weight368.41
FormulaC₁₈H₁₆N₄O₃S
Research AreaCancer

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(1) BE screen reveals METTL3 S2 dephosphorylation sensitizes gastric cancer cells to oxaliplatin by interfering METTL3-eIF3H interactionSci AdvDecember 12, 2025Xiaoran Xu, Wanyu Tao, Yixin Liu, Tangxi Guo, Yu Zhang, Dongyi Wei, Picheng Yan, Xingxu Huang, Yongchang Wei(HY-90006, MCE), cisplatin (HY-17394, MCE), irinotecan (HY-16562, MCE), ulixertinib (HY-15816, MCE), VE-821(HY-14731, MCE), AZD-7762 (HY-10992, MCE), and JQ1 (T2110, TargetMol). Plasmid: Lenti-single-guide RNA (sgRNA)-mCherry-puro

(2) Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistanceCell ReportsNovember 25, 2025Gatikrushna Singh, Shilpi Singh, Iteeshree Mohapatra, Stefan Kim, Mayur Sharma, Johnny Akers, Thien Nguyen, Eric Wong, Margot Martinez Moreno, Efrosini Kokkoli, et al.recombinant proteins" ,, Temozolomide,Sigma-Aldrich,T2577 Actinomycin D1,Gibco,11805017 VE821,MCE,HY-14731 TRIzol reagent,Invitrogen,15596026 DMSO,Sigma-Aldrich,D2438 Dynabeads M-280 Streptavidin,Invitrogen,11206D Dynabeads

(3) RECQ5 mediates pre-rRNA processing in nucleolusNucleic acids researchAugust 11, 2025Ma Y, Yu X.2348), anti-TOPBP1 (Santa Cruz, Mouse, sc-271043), anti-APE1 (Santa Cruz, Mouse, sc-17774), VE-821(MCE, HY-14731), RECQ5-IN-1(RECQ5 inhibitor, MCE, HY-145685), BMH-21 (Selleck, S7718), ATP-γ-S (MCE, HY-10866), BLM

(4) Senataxin prevents replicative stress induced by the Myc oncogeneCell Death DisMarch 19, 2025Silvia Sberna, Marco Filipuzzi, Nicola Bianchi, Ottavio Croci, Federica Fardella, Chiara Soriani, Sara Rohban, Sara Carnevali, Alessandra Alberta Albertini, Nicola Crosetto, et al.KU55933 (ATM inhibitor, MedChemTronica cat. no. HY-12016), VE821 (ATR inhibitor, MedChemExpress cat. no. HY-14731) or NU7441 (DNA-PK inhibitor, Bio-Techne cat. no. 3712) diluted in DMSO. After 72 h of drug treatment,

(5) Radiotherapy‐resistant prostate cancer cells escape immune checkpoint blockade through the senescence‐related ataxia telangiectasia and Rad3‐related proteinCancer CommunicationsDecember 19, 2024Chenyi Shao, Yingyi Zhang, Hang Li, Jiajia Chen, Ting Huang, Jiaze Li, Simeng Wen, Sen Wang, Saijun Fan, Yu Zhaocompounds Equal volumes of DMSO (D8371, Solarbio) and ATR/Atr inhibitors (ATRis/Atris), including VE‐821 (HY‐14731, MedChemExpress), VE‐822 (S7102, Selleck, Houston, TX, USA), and ceralasertib (HY‐19323, MedChemExpress),

(6) Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assaysElifeNovember 11, 2024Jonathan G Van Vranken, Jiaming Li, Julian Mintseris, Ting-Yu Wei, Catherine M Sniezek, Meagan Gadzuk-Shea, Steven P Gygi, Devin K Schweppecompound,Sotrastaurin,MedChemExpress,HY-10343, Chemical compound,AZ 628,MedChemExpress,HY-11004, Chemical compound,VE-821,MedChemExpress,HY-14731, Chemical compound,Entinostat,MedChemExpress,HY-12163, Chemical compound,Filanesib,MedChemExpress,HY-15187, Chemical

(7) 14-3-3σ downregulation sensitizes pancreatic cancer to carbon ions by suppressing the homologous recombination repair pathwayAging (Albany NY)June 15, 2024Dandan Wang, Hongtao Luo, Yanliang Chen, Yuhong Ou, Meng Dong, Junru Chen, Ruifeng Liu, Xiaohu Wang, Qiuning Zhanganalyzed no less than 100 cells per condition to quantify IF experiments. Drug treatment VE-821 (HY-14731), an ATR inhibitor, and KU-55933 (HY-12016), an ATM inhibitor, were purchased from MedChemExpress (Monmouth

(8) RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinomaJournal of experimental & clinical cancer research : CRSeptember 15, 2022Tu Q, Liu X, Yao X, Li R, Liu G, Jiang H, Li K, Chen Q, Huang X, Chang Q, et al.MedChemExpress (Cat. no. HY-10032). ATR antagonist VE-821 was purchased from MedChemExpress (Cat. no. HY-14731). HIF1α antagonist PX-478 was purchased from MedChemExpress (Cat. no. HY-10231). HIF2α antagonist PT-2385

(9) NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrestNucleic acids researchSeptember 18, 2020Sun X, Wang Y, Ji K, Liu Y, Kong Y, Nie S, Li N, Hao J, Xie Y, Xu C, et al.(H+L) (Proteintech, SA00003-2). The following reagents and kits were used: VE-821 (MedChemExpress, USA, HY-14731), KU-55933 (MedChemExpress, USA, HY-12016), brusatol (Tauto Biotech, Shanghai, China), propidium iodide

(10) BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cellsOncogeneSeptember 8, 2016Muralidharan SV, Bhadury J, Nilsson LM, Green LC, McLure KG, Nilsson JA.

(11) The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapyCancer biology & therapySeptember 1, 2012Prevo R, Fokas E, Reaper PM, Charlton PA, Pollard JR, McKenna WG, Muschel RJ, Brunner TB.

(12) Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agentsJournal of medicinal chemistryApril 14, 2011Charrier JD, Durrant SJ, Golec JM, Kay DP, Knegtel RM, MacCormick S, Mortimore M, O'Donnell ME, Pinder JL, Reaper PM, et al.

(13) Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATRNature chemical biologyApril 13, 2011Reaper PM, Griffiths MR, Long JM, Charrier JD, Maccormick S, Charlton PA, Golec JM, Pollard JR.

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VE-821 from MedChemExpress

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VE-821 from MedChemExpress

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