Digitonin from MedChemExpress

Product Specs
ItemDigitonin
CompanyMedChemExpress
Price $33.00Supplier Page View Company Product Page
Catalog NumberHY-N4000
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
TypeChemical
Molecular Weight1229.31
FormulaC₅₆H₉₂O₂₉
Research AreaCancer

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(1) The critical role of Atpif1 in Her2-targeted CAR-T cell therapy for solid tumor via modulation of metabolism and mtDNA-STING signal pathwayFront ImmunolMarch 2, 2026Genshen Zhong, Biao Liu, Xue Gong, Qi Wang, Shuyin Zheng, Xinyu Luo, Zhiguo Chen, Xingya Zhang, Biliang Hu, Minna Wuresuspended in 170 μl of digitonin buffer containing 150 mM NaCl, 50 mM HEPES, pH 7.4 and 25 μg/ml digitonin (HY-N4000, MedChemExpress). The homogenates were incubated on a rotator for 10 min at room temperature, followed

(2) A Novel FGFR3‐Targeting Antibody‐Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS–STING Pathway in Bladder CancerAdvanced ScienceJanuary 1, 2026Shu Cui, Xiongfei Luo, Guangrui Fan, Jingqi Jiang, Yingru Wang, Enguang Yang, Jinpeng Ma, Ze Zhang, Yuhan Wang, Juan Wang, et al.in permeabilization buffer (150 mm NaCl, 2 mm EDTA, 50 mm HEPES (pH 7.4), and 50 µg mL−1 digitonin (HY‐N4000, MCE, USA)) for 10 min, followed by centrifugation at 17 000 × g for 10 min. Both genomic and cytosolic

(3) SARS-CoV-2 NSP3/4 control formation of replication organelle and recruitment of RNA polymerase NSP12Journal of Cell BiologyMarch 3, 2025Jinping Yang, Buyun Tian, Pei Wang, Rongrong Chen, Ke Xiao, Xubing Long, Xinyue Zheng, Yun Zhu, Fei Sun, Yongxia Shi, et al.Anti-Mouse IgG and Dylight 800(A23910), and Goat Anti-Mouse IgG were purchased from Abbkine. Digitonin (HY-N4000) and remdesivir (GS-5734) were purchased from MedChemExpress. Hochest (23491-45-4) and glutaraldehyde

(4) Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytesThe EMBO JournalNovember 4, 2024Min Xu, Zi-yue Chen, Yang Li, Yue Li, Ge Guo, Rong-zheng Dai, Na Ni, Jing Tao, Hong-yu Wang, Qiao-li Chen, et al.(LPEI),PolyScience,24314-2 Tyloxapol,Sigma,T0307 Iodixanol,Merck,D1556 Lipofectamine-3000,Thermo Fisher,100022052 A769662,MCE,HY-50662 Atglistain,MCE,HY-15859 Digitonin,MCE,HY-N4000 HSL-IN-3,MCE,HY-15859 LipidTOX,Thermo Fisher,H34477 LysoTracker,Invitrogen,L7528 BODIPY,Thermo Fisher,D3922 DAPI,Biosharp,BL105A BODIPY™

(5) Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1Cell reportsJuly 25, 2023Ma Y, Zhao R, Guo H, Tong Q, Langdon WY, Liu W, Zhang J, Zhang J.144189-73-1 phorbol 12-myristate-13-acetate (PMA),Sigma-Aldrich,Cat# 16561-29-8 Digitonin,MedChemExpress (MCE),Cat# HY-N4000 Biotin-conjugated LPS,InvivoGen,Cat# tlrl-lpsbiot FITC-conjugated LPS,Sigma-Aldrich,Cat# F8666 Streptavidin-sepharose

(6) Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunityCell researchDecember 1, 2022Gao Y, Zheng X, Chang B, Lin Y, Huang X, Wang W, Ding S, Zhan W, Wang S, Xiao B, et al.antibody (A2095) were from Sigma-Aldrich. DiABZI STING agonist-1 (Tautomerism) (HY-112921) and Digitonin (HY-N4000) were from MCE. HaloTag® Ligands (GA1110) for super-resolution microscopy were from Promega. 2'3'-cGAMP

(7) ATF3 -activated accelerating effect of LINC00941/lncIAPF on fibroblast-to-myofibroblast differentiation by blocking autophagy depending on ELAVL1/HuR in pulmonary fibrosisAutophagyNovember 1, 2022Zhang J, Wang H, Chen H, Li H, Xu P, Liu B, Zhang Q, Lv C, Song X.Scientific, 85,124], 0.1% Tween-20 [Thermo Scientific, 28,320], 0.01% digitalis saponin [MedChemExpress, HY-N4000]) was added to 5 × 104 living cells, which were incubated on ice for 3 min. Then, 1 mL pre-cooled RSB

(8) Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via sonic hedgehog signalingJCI insightFebruary 22, 2022Shi H, Wang H, Zhang C, Lu Y, Yao J, Chen Z, Xing G, Wei Q, Cao X.The regents used in this study included Smoothened Agonist (Sigma-Aldrich, 566661); Digitonin (MCE, HY-N4000); FLAG Immunoprecipitation Kit (Millipore, FLAGIPT1); DAPI (Sigma-Aldrich, F6057); and isopropyl β-D-thiogalactoside

(9) In meso crystallogenesis. Compatibility of the lipid cubic phase with the synthetic digitonin analogue, glyco-diosgeninJournal of applied crystallographyApril 1, 2020van Dalsen L, Weichert D, Caffrey M.

(10) Digitonin enhances the efficacy of carboplatin in liver tumour after intra-arterial administrationCancer chemotherapy and pharmacologyJanuary 1, 1997Lindnér PG, Heath D, Howell SB, Naredi PL, Hafström LR.

(11) Monitoring exposure to propylene oxide through the determination of hemoglobin alkylationScandinavian journal of work, environment & healthApril 1, 1984Osterman-Golkar S, Bailey E, Farmer PB, Gorf SM, Lamb JH.

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Digitonin from MedChemExpress

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Digitonin from MedChemExpress

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