AP20187 from MedChemExpress

Product Specs
ItemAP20187
CompanyMedChemExpress
Price $816.00Supplier Page View Company Product Page
Catalog NumberHY-13992
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.85%
TypeChemical
Molecular Weight1482.75
FormulaC₈₂H₁₀₇N₅O₂₀
Research AreaMetabolic Disease

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(1) Tollip antagonizes ESCRT-III-mediated plasma membrane repair and cell recoveryCell RegenMay 19, 2026Julia M. Ferrick, Xinan Meng, Emily Morgan, Anthony Kalvi, Zhen Li, Chaoqun Li, Chao-Yuan Chang, Suhong Xu, Yi-Nan Gongpan-caspase inhibitor z-VAD-FMK (ApexBio, Cat No. A1902-25) (TSZ), B/B homodimerizer (MCE, Cat No. HY-13992), or digitonin (TCI America, Cat No. TCD0540). Reagents were mixed with cell culture medium, with cell

(2) Two axolotl-adapted cell-ablation platforms reveal macrophage-dependent processes essential for spinal-cord and skeletal regenerationbioRxivFebruary 14, 2026Gabriela Johnson, Andrew Hart, Markus Sujansky, Joel H. Graber, James W. Godwinthen directly administered. B/B Homodimerizer, alternatively known as AP20187 (MedChemExpress cat. HY-13992), was solubilized in DMSO to make a 74.14 mg/ml (50 mM) stock solution stored in 10 ul aliquots at −

(3) Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypesJournal of Clinical InvestigationJanuary 27, 2026Madison L. Doolittle, Mitchell N. Froemming, Jennifer L. Rowsey, Ming Ruan, Leena Sapra, Joshua N. Farr, David G. Monroe, Sundeep Khosla(4% ethanol, 10% polyethylene glycol 400, and 2% Tween) or 10 mg/kg AP20187 (MedChemExpress catalog HY-13992) dissolved in vehicle, administered by intraperitoneal injection twice weekly. For each experiment,

(4) Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypesJ Clin InvestJanuary 27, 2026Madison L. Doolittle, Mitchell N. Froemming, Jennifer L. Rowsey, Ming Ruan, Leena Sapra, Joshua N. Farr, David G. Monroe, Sundeep Khosla(4% ethanol, 10% polyethylene glycol 400, and 2% Tween) or 10 mg/kg AP20187 (MedChemExpress catalog HY-13992) dissolved in vehicle, administered by intraperitoneal injection twice weekly. For each experiment,

(5) Senescence-induced endothelial-to-mesenchymal transition accelerates the subretinal fibrosis in neovascualr age-related macular degenerationJournal of Translational MedicineJanuary 22, 2026Yinhao Wang, Huiling Ma, Jiayun Ge, Kuangqi Chen, Kai Chen, Hui Ye, Xinlei Pan, Xinglin Wang, Jianhua Xia, Jianqin Shen, et al.mice experiments, we injected with either 1 µl of B/B Homodimerizer (AP20187; MedChemExpress, Cat. No. HY-13992, USA) or vehicle control at day 7 post injury. Animals were sacrificed and evaluated 4 weeks after laser

(6) Protocol for specific induction of apoptosis or necroptosis in established murine tumorsSTAR ProtocolsDecember 1, 2025Kay Hänggi, Brian RuffellAccuCheck counting beads,Thermo Fisher Scientific,Cat# PCB100 AP20187 (BB-Homodimerizer),MedChemExpress,Cat# HY-13992 BD Cytofix fixation buffer,BD Biosciences,Cat# 554655 BD Perm/Wash Buffer,BD Biosciences,Cat# 554723 Bovine serum albumin (BSA

(7) RIPK1 S213E mutant suppresses RIPK1-dependent cell death by preventing interactions with RIPK3 and CASP8Cell Death DiscovJuly 25, 2025Ning Nan, Hong Hu, Xinxin Zhu, Jia Liu, Feiyang Yuan, Zhijie Li, Huayi WangPoly I:C (HY-107202), TAKi (HY-103490), TPCA-1 (HY-10074), NEC-1 (HY-15760), NSA (HY-100573), AP20187 (HY-13992) were purchased from MCE. CL-hPARP1 antibody was the gift from Dr. Gaofeng Fan of Shanghaitech University,

(8) Senescent cell reduction does not improve recovery in mice under experimental autoimmune encephalomyelitis (EAE) induced demyelinationJournal of neuroinflammationApril 7, 2025Manavi Z, Melchor GS, Bullard MR, Gross PS, Ray S, Gaur P, Baydyuk M, Huang JK.(AP) treatment, INK-ATTAC;EAE mice were administered AP (2 mg/kg, MedchemExpress B/B homo-dimerizer, HY-13992) or vehicle (4% DMSO, 10% PEG400, 1.72% tween 20). AP, or vehicle, was injected intraperitoneally twice

(9) Senescent-like microglia limit remyelination through the senescence associated secretory phenotypeNature communicationsMarch 7, 2025Gross PS, Durán-Laforet V, Ho LT, Melchor GS, Zia S, Manavi Z, Barclay WE, Lee SH, Shults N, Selva S, et al.were treated twice a week intraperitoneally with AP20187 (2 mg/kg, MedchemExpress B/B homodimerizer, #HY-13992) or with vehicle (10% DMSO, 40% peg400, 5% tween 80, 45% saline) at equal volumes (10 μL/g bodyweight)

(10) Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunityCancer cellDecember 9, 2024Hänggi K, Li J, Gangadharan A, Liu X, Celias DP, Osunmakinde O, Keske A, Davis J, Ahmad F, Giron A, et al.PCB100 Antimicrobial Reagent,Invivogen,Cat# ant-noc AP20187 (BB-Homodimerizer),MedChemExpress,Cat# HY-13992 BAY 11–7085 (NF-κB inh.),MedChemExpress,Cat# HY-10257 BD Cytofix fixation buffer,BD Biosciences,Cat#

(11) Caspase-1 activates gasdermin A in non-mammalsElifeMarch 18, 2024Zachary Paul Billman, Stephen Bela Kovacs, Bo Wei, Kidong Kang, Ousmane H Cissé, Edward A Miaocells received the same amount of DNA with backbone pcDNA3 making up differences in mass. AP20187 (HY-13992, MedChemExpress, Monmouth Junction, NJ, USA) was added to cells by replacing supernatant with OptiMEM

(12) Caspase-1 activates gasdermin A in non-mammalsElifeMarch 18, 2024Zachary Paul Billman, Stephen Bela Kovacs, Bo Wei, Kidong Kang, Ousmane H. Cissé, Edward A. Miaocells received the same amount of DNA with backbone pcDNA3 making up differences in mass. AP20187 (HY-13992, MedChemExpress, Monmouth Junction, NJ, USA) was added to cells by replacing supernatant with OptiMEM

(13) PD-L1ATTAC mice reveal the potential of depleting PD-L1 expressing cells in cancer therapyAging (Albany NY)March 31, 2023Elena Fueyo-Marcos, Gema Lopez-Pernas, Coral Fustero-Torre, Marta Elena Antón, Fátima Al-Shahrour, Oscar Fernández-Capetillo, Matilde MurgaAnimal Research of the “Instituto de Salud Carlos III”. AP20187 treatments AP20187 (MedChemExpress, HY-13992) was resuspended in 75% EtOH at 62.5 mg/ml and stored at −20°C. For in vitro experiments, cells were

(14) Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine productionCell death & diseaseOctober 23, 2021Zu R, Yu Z, Zhao J, Lu X, Liang W, Sun L, Si C, Zhu K, Zhang T, Li G, et al.PD-407824 (Sigma-Aldrich, PZ0111), BHT (Sigma-Aldrich, 34750), BHA (Sigma-Aldrich, 20021), AP20187 (MCE, HY-13992). R-7-Cl-O-Nec-1(Nec-1s), zVAD.fmk and SM164 were made by custom synthesis. Final concentrations of

(15) Discovery of a cooperative mode of inhibiting RIPK1 kinaseCell discoveryJune 1, 2021Meng H, Wu G, Zhao X, Wang A, Li D, Tong Y, Jin T, Cao Y, Shan B, Hu S, et al.gel stain (Life Technologies, #s6651); 5Z7 (Sigma-Aldrich, #O9890); dimerizing agents AP20187 (MCE, #HY-13992); Sf-9 cell medium ESF-921 (ExpressionSystems, #96-001-01); ADP-Glo™ kinase assay (Promega, #V6930). Cell culture

(16) Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent mannerThe EMBO journalMay 3, 2021Lagnado A, Leslie J, Ruchaud-Sparagano MH, Victorelli S, Hirsova P, Ogrodnik M, Collins AL, Vizioli MG, Habiballa L, Saretzki G, et al.INK‐ATTAC mice were injected intraperitoneally (i.p.) with AP20187 (10 mg/kg) (MCE MedchemExpress; Cat: # HY‐13992/CS1953) or vehicle (4% ethanol, 10% PEG‐400, and 2% Tween‐20 in distilled water) for 3 days every 2

(17) RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motifCell Death & DifferentiationJanuary 1, 2021Hong Hu et al.previously [24]. Recombinant TNF and IFN-γ were purified in our lab. Necrostatin-1 (HY-15760) and AP20187 (HY-13992) are bought from MCE. Anti-ICP6 polyclonal antibodies were raised in rabbits using E. coli-expressed

(18) ICP6 Prevents RIP1 Activation to Hinder Necroptosis SignalingFrontiers in Cell and Developmental BiologyOctober 30, 2020Hong Hu, Guoxiang Wu, Zhaoqian Shu, Dandan Yu, Ning Nan, Feiyang Yuan, Xiaoyan Liu, Huayi Wangdescribed previously (Wang H. et al., 2014). Recombinant TNF was purified in our laboratory, AP20187 (HY-13992) was purchased from MCE. ICP6 polyclonal antibodies can be obtained by injecting His-ICP6 (1-177 amino

(19) Obesity-Induced Cellular Senescence Drives Anxiety and Impairs NeurogenesisCell metabolismMay 7, 2019Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, et al.groups. INK-ATTAC mice were injected intraperitoneally (i.p.) with AP20187 (10mg/kg) (MCE MedchemExpress; Cat: # HY-13992/CS-1953) or vehicle (4% ethanol, 10% PEG-400, and 2% Tween-20 in distilled water) for 3 days every 2

(20) Caspase-1 initiates apoptosis in the absence of gasdermin DNature communicationsMay 7, 2019Tsuchiya K, Nakajima S, Hosojima S, Thi Nguyen D, Hattori T, Manh Le T, Hori O, Mahib MR, Yamaguchi Y, Miura M, et al.science (December 2012). Reagents Val-boroPro (MedChemExpress, HY-13233A); AP20187 (MedChemExpress, HY-13992); Poly dA:dT (Sigma-Aldrich, P0883); Lipopolysaccharides from Escherichia (E.) coli K-235 (Sigma-Aldrich,

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AP20187 from MedChemExpress

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AP20187 from MedChemExpress

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